Notable East Coast restauranteur Stephen Starr wanted to include a seafood place among his other hotspots in Philly, New York, DC and Florida, and the name Route 6 came to mind because "Route 6 is the main road through Cape Cod." Little did he (or his PR people) know that the Route 6 in Cape Cod extends all the way to California, and ironically runs 440 miles along the northern border of Pennsylvania.
No matter. They will soon. Meanwhile, when you're in town, try a lobsta or fried clam with a swig of specially brewed, unfiltered Rye ESB called Route 6 Ale, at the one and only Route 6 in Philadelphia!
I wish it many successful years!